His dismissal was shortly after 0830 BST, after a meeting with executive known Vice President Ed Woodward at the training ground of the Club.
Moyes - of "Chosen One" to dismissMoyes, 50, was elected by Ferguson as his successor when he retired after 26 years in free last summer.
United said player-manager of Ryan Giggs will assume control, "until a permanent appointment can be made".
His first match as interim Chief is the home game against Norwich on Saturday.
The BBC understands coaches Steve Round and Jimmy Lumsden have left their contributions, but remain goalkeeping coach of Chris Woods, first team coach Phil Neville with the Club for the rest of the season.
Commenting on United rejected newspaper reports on Monday, the Moyes to sign former Everton to a six-year contract, be dismissed before the end of the season with the Premier League champions would.
Champions League defeated in the quarter-finals by Bayern Munich beaten in the League Cup semi-finals of Sunderland lost at home against Swansea in the third round of the FA Cup five points from a possible 24 against the current Premier League Top 4 which defeat against Everton confirmed arsenal, Liverpool, Chelsea and Manchester City Club will miss Champions League for the first time since 1995 / 96 however these reports Club officials, Talks with Moyes on Monday in late a maneuver, called on to prevent a protracted dismissal process.And in a brief statement on Tuesday, the club said leave Moyes had, adding that it "to Protocol type, his thanks for all the hard work, he brought honesty and integrity the role would".
Coach Louis van Gaal, Borussia Dortmund head Jürgen Klopp Netherlands, Atletico Madrid Manager Diego Simeone and Paris St-Germain Laurent Blanc have already as a possible successor has been tipped.
But Klopp has the chosen guardian from the order who say 46-year-old: "Utd is a great club and I am very familiar with their wonderful fans. "But my commitment for Borussia Dortmund and the people is not fragile."
Telegraph recommend the daily to see whether PEP Guardiola can be persuaded, to leave Bayern Munich, make will United also discrete movements.
Combined, the seventh in the table with four games remain, are are guaranteed to record their lowest points counter in the Premier League have fight in the Old Trafford of especially this season.
Under Moyes, they lost six League games at home, been beaten in the FA Cup by Swansea at Old Trafford and were able to prevent them in the capital one Cup semi-final against Sunderland.
In March, some supporters chartered an airplane fly overhead during their Premier League match against Aston Villa trailing a banner with the words "a wrong - Moyes out", a reference to the banner at Old Trafford, the announced Moyes, the "chosen" be.
A bystander dressed as the grim reaper of Moyes United mocked in his last match for ManchesterThe Red Devils will miss Champions League football for the first time since 1995 and total run the risk not to European competition for the first time since 1990.
United reached the quarter-finals of the Champions League before by Bayern Munich and Moyes is unconscious argues, that was their best display in the competition.
But the Scot was accompanied by persistent, claims that he has fallen has his squad by.
As midfielder Anderson loaned to Serie a. Fiorentina in January, he has been cited other players say "get out was" United, although he later denied it.
Rio Ferdinand and Robin van Persie made posted cryptic quotes on Twitter even less than free comments about his management style, while Javier Hernandez and Wilfried Zaha.
The sacking of Moyes was inevitable after Sunday's terrible performance at Everton.
A backstage source characterized the performance as "missing, lust and passion" and "Basic heart of the team is gone". It had for some time which seemed players were tried for Moyes. This confirms it.
In truth the Scot has never studied lightness in the work. He was taken aback by the sheer scope of the media interest in the United States and has impressed the players, more medals than he can ever hope to collect.
The big problem for United is that word on the appointment, to whom they turn Sir Alex Ferguson now?
The weekend Manchester was reported born striker Danny Welbeck his future after always disappointed that is played regularly, pulled out of his preferred position into account.After 11 seasons, saying he could not turn the way, Old Trafford move and began its work on 1 July Moyes Everton left.
United endured a difficult summer transfer window and not reported offers for Barcelona Thiago Alcántara and CESC Fabregas.
A double bid for Marouane Fellaini and Leighton Baines was dismissed as "ridiculous and insulting" by Moyess of old club FC Everton, although Fellaini on the day of the transfer deadline for £27. 5m.
Moyes was unhappy United were given a difficult start to the season, Chelsea, Liverpool and Manchester City in their first five games to play.
"I find it hard to believe that this is so, came the eggs out of the bag, that's for sure," he said.
But his reign began Sunday with a 2-0-win against Wigan Athletic in the community shield at Wembley Stadium, followed by a 4-1-victory away at Swansea city in the first League game of the season.
Archive: Moyess turbulent seasonHowever, things worsened quickly with defeats at Anfield and Etihad Stadium, tone for what would be the worst Premier League season.
With the exception of the additional 21 games Matt Busby (Manager from 1945 to 1969) had in free as emergency Manager Wilf McGuinness exit in 1970 and the 22 games, when Jimmy Murphy for Busby after Munich jumped a air crash, Moyess rule the third shortest in the history of the United States is.
It is also the first time that Manchester United have dismissed a Manager since November 6, 1986.
The Scotsman games 51 say exceeds 43 goals which is Walter Crickmer, during the first two spells as Manager.
Lal Hilditch was responsible for the shortest time only 33 games October 1926 and April 1927.